283 ‒ Gut health, the microbiome: improving and maintaining the microbiome, probiotics, more

View show notes here: https://bit.ly/3GJjQKzBecome a member to receive exclusive content: https://peterattiamd.com/subscribe/Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more.We discuss:0:00:00 - Intro0:00:34 - Colleen’s background and current focus0:03:08 - The basics of the microbiome0:12:37 - The study of the human microbiome0:17:42 - Categories of bacteria, and the implications on health of the rapid evolution of bacteria0:27:51 - Methods for measuring and understanding the microbiome, and key indicators of microbiome health0:39:52 - The important role of fiber for promoting gut health through the production of butyrate0:47:21 - The case for manipulating gut bacteria via fecal microbiota transplant (FMT)0:53:25 - Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function0:59:16 - Factors that influence the vaginal microbiom1:03:46 - The effect of gut microbes on obesity and challenges with fecal transplants in people1:06:25 - Beneficial strains of gut bacteria and strains commonly found in probiotics1:16:35 - The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient”1:21:47 - Considerations about how probiotic strains are produced, and more on the meaning of CFU1:31:12 - Mitigating the effect of antibiotics on the microbiome1:39:58 - What do we know about the effect of artificial sweeteners on the gut microbiome?1:47:02 - Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions1:58:14 - The essential steps necessary to develop a robust probiotic for optimal health support2:01:45 - How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more2:22:46 - Pendulum Therapeutics’ commitment to rigorous product develop2:29:54 - Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics2:38:43 - Further studies of Akkermansia that have been proposed or are underway--------About:The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Learn more: https://peterattiamd.comConnect with Peter on:Facebook: http://bit.ly/PeterAttiaMDFBTwitter: http://bit.ly/PeterAttiaMDTWInstagram: http://bit.ly/PeterAttiaMDIGSubscribe to The Drive:Apple Podcast: http://bit.ly/TheDriveApplePodcastsOvercast: http://bit.ly/TheDriveOvercastSpotify: http://bit.ly/TheDriveSpotifyGoogle Podcasts: http://bit.ly/TheDriveGoogleDisclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/
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