How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks | Huberman Lab Podcast

In this episode, I discuss what psilocybin is (chemically) and how it works at the cellular and neural circuit level to trigger neuroplasticity, which is our brain’s ability to rewire itself in ways that lead to long-lasting shifts in our emotional, cognitive and behavioral patterns and abilities. I discuss the emerging clinical trial evidence for the use of psilocybin in the treatment of depression, addictions and other psychiatric challenges. I explain the typical duration and phases of a psilocybin journey, the different categories of dosages often used and I explain the importance of set, setting and support when using psychedelics. I explain which groups of people place themselves at great risk by taking psilocybin as well as groups that could benefit, and I highlight the rapidly changing legal and medical landscape around psilocybin. This episode is a thorough exploration of psilocybin from the scientific and clinical literature perspective and ought to be of interest to anyone curious about psilocybin, mental health, neuroplasticity and/or psychedelics more generally.#HubermanLab #Science Thank you to our sponsorsAG1 (Athletic Greens): https://athleticgreens.com/hubermanEight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com code: “Huberman”LMNT: https://drinklmnt.com/huberman Supplements from Momentoushttps://www.livemomentous.com/hubermanSocial & WebsiteInstagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab LinkedIn: https://www.linkedin.com/in/an....drew-hubermanWebsite https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-networkArticlesThe neural basis of psychedelic action: https://go.nature.com/3VInMlEThe effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers: https://bit.ly/3VW8iL7Increased low-frequency brain responses to music after psilocybin therapy for depression: https://bit.ly/3LKj6XKQuality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression: https://bit.ly/42c7y6xBrief structured respiration practices enhance mood and reduce physiological arousal: https://bit.ly/3wEvGRfTherapeutic use of psilocybin: Practical considerations for dosing and administration: https://bit.ly/3HPHLZMPsilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo: https://bit.ly/3HQ8J3zPsychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics: https://bit.ly/44GpwjxSingle-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression: https://bit.ly/3pjvu9NEffects of Psilocybin-Assisted Therapy on Major Depressive Disorder: https://bit.ly/3sFSGMMThe costs and benefits of psychedelics on cognition and mood: https://bit.ly/3NNyEwIOther ResourcesThe Physiological Sigh: https://youtu.be/rBdhqBGqiMcDr. Matthew Johnson: Psychedelic Medicine: https://hubermanlab.com/dr-matthew-johnson-psychedelic-medicineTimestamps00:00:00 Psilocybin, Legal Considerations00:08:32 Sponsors: Eight Sleep, ROKA, HVMN 00:12:00 Psilocybin Becomes Psilocin in the Gut, Serotonin 00:17:00 The Serotonin 2A Receptor, Therapeutic Outcomes SSRIs vs. Psilocybin00:21:40 Serotonin Receptor Expression; Visual Hallucinations & Eyes Closed00:27:21 Safety & Cautions for Specific Patient Populations00:29:13 Sponsor: AG1 (Athletic Greens)00:30:28 Psilocybin, “Magic Mushrooms” Dosing, Micro-Dosing, “Heroic Doses”00:36:21 Psychedelic Journey: Set, Setting & Support00:43:43 Music & the Psilocybin Journey; Duration of Effects00:48:58 Psilocybin & the Brain: Subjective Experiences, Perception00:58:36 Sponsor: LMNT00:59:48 Brain Networks & Therapeutic Outcomes01:05:23 Creativity; Music, Emotionality & Psychedelic Journeys01:12:39 Depression & Psychedelics as Neuroplasticity “Wedge”01:16:53 Positive Psychedelic Journeys, Unity, “Oceanic Boundlessness”01:25:23 “Bad Trips”, Anxiety & Physiological Sighs01:32:57 Therapeutic Use of Psilocybin01:36:11 Neuroplasticity, Structural Brain Changes & Psilocybin01:48:08 Psychedelics: Therapeutic Breakthroughs & Depression 01:56:37 Combining Psilocybin Therapy & Talk Therapy, Antidepressant Effects02:03:11 Psilocybin Experience & Mental Health02:06:42 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social MediaTitle Card Photo Credit: Mike Blabac - https://www.blabacphoto.comDisclaimer: https://hubermanlab.com/disclaimer
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